| Rank |
City |
Country |
Population |
Year |
| Brazil |
| 1 | São Paulo | Brazil | 11,316,149 | 2011 |
| 6 | Rio de Janeiro | Brazil | 6,355,949 | 2011 |
| 11 | Salvador | Brazil | 2,693,605 | 2011 |
| 13 | Brasília | Brazil | 2,609,997 | 2011 |
| 14 | Fortaleza | Brazil | 2,476,589 | 2011 |
| 15 | Belo Horizonte | Brazil | 2,385,639 | 2011 |
| Mexico |
| 2 | Mexico City | Mexico | 8,851,080 | 2010 |
| United States |
| 3 | New York City | United States | 8,175,133 | 2010 |
| 8 | Los Angeles | United States | 3,792,621 | 2010 |
| 10 | Chicago | United States | 2,695,598 | 2010 |
| Colombia |
| 5 | Bogotá | Colombia | 7,467,804 | 2011 |
| 17 | Medellín | Colombia | 2,343,049 | 2010 |
| 18 | Santiago de Cali | Colombia | 2,219,714 | 2010 |
| Others |
| 4 | Lima | Peru | 7,605,742 | 2007 |
| 7 | Santiago | Chile | 5,040,028 | 2010 |
| 9 | Buenos Aires | Argentina | 2,891,082 | 2010 |
| 12 | Toronto | Canada | 2,615,060 | 2011 |
| 16 | Guayaquil | Ecuador | 2,366,902 | 2008 |
| 19 | Santo Domingo | Dominican Republic | 2,169,300 | 2010 |
| 20 | Havana | Cuba | 2,135,498 | 2010 |